Apolipoprotein E

Apolypoprotein E (apo E) is a protein component of numerous plasma lipoproteins (chylomicrons, VLDL, IDL, HDL) and is also present in the in cerebrospinal fluid.
Apolipoprotein E plays an important role in the prevention of atherosclerosis It transports lipids from the site of their formation or absorption to the tissues, where they are stored or excreted from the body, and Transports lipids, particularly cholesterol, from the organs of the peripheral organs to the liver for excretion.
The main site of apo E synthesis is liver cells. It is also synthesized in peripheral cells (macrophages, astrocytes) and in the lungs, kidneys, spleen, muscles.
One variant of the apo E gene increases the risk of the disease Alzheimer's disease.