Immunoglobulin A - one of the immuglobulins of the immune system
organism occurring in serum - monomeric and
secretory - dimeric. Secretory IgA is found in
mucosal-serum secretions such as milk and colostrum, saliva,
tears, nasopharyngeal, bronchial, intestinal and genitourinary tract secretions
urogenital tract. IgA is responsible for bacterial agglutination,
inhibiting bacterial adhesion to the epithelium of mucous membranes and also
neutralization of bacterial toxins. IgA, due to its structure and
occurrence in the body is divided into two subclasses IgA1 and IgA2 with
different biological activity and distribution in the body. IgA1
predominates in serum IgA, while the IgA2 subclass is found mainly on the
the surface of mucous membranes. IgA deficiency is the most common cause of immune deficiency
immunodeficiency. Clinical manifestations include recurrent infections of the
of the upper respiratory tract. IgA deficiency can be accompanied by diseases of an
autoimmune nature as well as other disorders of immunity
humoral immunity (decreased production of IgG, increased production of
IgE).
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