M2 isoform of pyruvate kinase (M2-PK)

Pyruvate kinase (PK) - an enzyme involved in glycolysis converting phosphoenolpyruvate to pyruvate with simultaneous ATP formation. PK occurs in the form of isoforms, in muscle and brain M1 tetrameric type, in the liver and kidney L-PK type. W erythrocytes type R. In cells with increased proliferation there is an enzymatically inactive dimeric form of M2-PK. An increase in M2-PK concentration in plasma and feces occurs in adenomas and colorectal neoplasms and in chronic inflammatory conditions intestines.