Homogentisic acid

Homogentisic acid - a test useful in diagnosing alkaptonuria, a disease involving a congenital disorder of the metabolism of tyrosine. The enzyme block involves the enzyme, homogentisic acid oxidase homogentisinic acid oxidase. The typical symptom often observed as the first is a change in the color (darkening) of urine left in the air air and at a later stage arthritis and degenerative changes degenerative changes of the spine.