Assessment of predisposition to endometriosis - EndomKIT test

The test is carried out from Monday to Friday at different hours depending on the selected collection point. For more information please contact the Synevo hotline: +48 22 120 24 00

Note! Patients may visit the Collection Point:

- with a referral from a gynecologist (example),

- without a referral.

If the patient comes in WITHOUT REFERRAL, it is necessary to fill out a questionnaire on your own (the questionnaire in pdf format can be downloaded HERE), whichóra is used to qualify for the study. It is also an indispensable and key part of the clinical data for the algorithm, allowing to make a diagnostic report.

What is Endometriosis?

Endometriosis is a gynecological disease that is characterized by the presence of uterine endometrium-like tissue in other locations in the body. The exact causes of the development of endometriosis are not fully understood. Diagnosis is most often made between the ages of 30 and 50, although the beginnings of the development of the disease can occur much earlier. The disease affects both reproductive and postmenopausal women. It can also be detected in girls before the onset of the first menstrual period.

From the inside, the uterine cavity is lined with a specialized tissue called endometrium. Its thickness and structure undergoes cyclic changes under the influence of hormonesórelated to the menstrual cycle. During menstruation, the endometrium is exfoliated and excreted with menstrual blood. In the course of endometriosis, clusters of endometrium-like cellsórek are observed outside the uterine cavity. Most often, endometriosis foci develop on the ovaries, fallopian tubes, ligaments surrounding the uterus and on the outer surface of the uterus. It is also possible for endometrium to appear in other anatomical locations, such as in the vagina, on the peritoneum, in the bladder and other pelvic organs.

These tissues are sensitive to the hormones responsible for regulating menstruation. This means that they undergo growth and exfoliation during menstruation. This results in the occurrence of internal bleeding and chronic inflammationóre which lead to the appearance of symptomsóre and can result in the formation of adhesionsóre, scars, cysts and other pathological changes.

Endometriosis - symptoms

In some cases, endometriosis is asymptomaticób. The severity of the discomfort and possible complications depend on a number of factorsóon, including the size and location of the lesions. The primary symptom of endometriosis is recurrent ból located in the pelvis. The severity of the bólu and its nature can range – from mild to very severe, stabbing in nature, whichóry can radiate to the lumbar region. Patients suffering from this condition also report severe bóle during menstruation, ovulation and bóle during sexual intercourse.

Additionally, menstrual disorders may occur. Monthly bleeding may be irregular, often more heavy with a significant increase in additional discomforts. Sometimes symptoms related to urinary and digestive disorders such as frequent urinary urgency, soreness during urination, hematuria, bloating, diarrhea, constipation, ból when passing feces are also observed.

Endometriosis is one of the causes of infertility in women. According to the WHO definition, infertility can be diagnosed if, despite regular sexual intercourse (3-4 per week) without the use of contraceptive methods for a period of 12 months, a woman does not become pregnant.

Endometriosis predisposition test - EndomKIT

Non-invasive test performed in blood drawn from the patient. The test consists in the first stage of determination of serum levels of CA 125 (cancer antigen 125) and BDNF (neurotrophic factor of mózg origin). In the next stage, on the basis of clinical data about the patient and the obtained concentrations of CA125 and BDNF with the help of specialized software and a diagnostic algorithm, a result is generated.

The test is useful for early detection of endometriosis in patients with suspected and symptomatic ednometriosis, pelvic bóls and/or infertility.

The test was validated against the gold standard in the diagnosis of endometriosis – laparoscopic examination with histopathological confirmation.

The result is presented as positive/negative.

In case of a positive result, the probability of endometriosis is close to 100%. In the case of a negative result, if the reason for the test was infertility then the probability that the patient does not have endometriosis is 85%, if the reason for the test was a ból in the small pelvis, then the probability that the patient does not have endometriosis is 65%.

Preparing for the test - EndomKIT

In the first part of the form there are four questions. The answers to these questions will allow the Patient to correctly qualify for the test on her own so as to avoid the situation where the Patient wants to take the test without indications. If, after answering these questions, the Patient qualifies for the test, she completes the second part of the form.

The second part contains questions about the Patient's clinical condition. All these questions are also answered by the Patient. Without the answers, it will not be possible to prepare a report and issue a test result.

Note!

The result of the test requires the interpretation of a gynecologist, whoóry will determine further diagnostic or therapeutic treatment based on it.

Test results should not be given to a gynecologist

The test should not be used in women who are pregnant or on hormonal treatment within 3 months preceding the test, or in the presence of other inflammatory diseases such as inflammatory bowel disease.