Anti-reticulin IgA antibodies

Reticulin antibodies are one of the serological markers of celiac disease (along with anti-gliadin antibodies, against tissue transglutaminase and against endomysial smooth muscle smooth muscle). Useful in the diagnosis of the disease is the determination of IgA class antibodies, as well as IgG. Celiac disease (visceral disease) is an autoimmune disease of known etiology and genetic background genetic basis. The cause of the disease is permanent intolerance to gluten, a protein contained in cereals such as wheat, barley and rye It causes an immune system reaction that results in the villi of the small intestine responsible for absorption of nutrients from food. Depending on the clinical picture clinical picture and the dynamics of the disease process, we distinguish the following forms classic form of the disease (full-blown) and atypical forms: silent (asymptomatic) and latent. The classical form of celiac disease refers to cases in which typical symptoms are observed with diarrhea and malabsorption syndrome. In the atypical form of the disease, symptoms gastrointestinal symptoms are absent or less pronounced and, in addition, may appear: iron deficiency anemia, early osteoporosis, skin lesions, infertility, and a tendency to miscarriage The concentration of IgA antibodies is directly correlated with exposure to to gluten and decreases with a gluten-free diet. In patients with suspected or confirmed deficiency of antibodies to class IgA antibody determination should be performed against reticulin IgG.