Package for PAPP-A test by FMF

PAPP-A test package by FMF
Conditions for performing the test:

• The test can be performed during the first trimester of pregnancy: 11 - 13 wks. + 6 days of pregnancy;
• A referral from the doctor in charge of the pregnancy should be provided
• Provide a description of the ultrasound ( performed max ±5 days ); 
• CRL in the range of 45-84 mm, NT value, name of the doctor performing the examination

The calculated risk values are valid only if the ultrasound was performed by an ultrasound doctor accredited by the Fetal Medicine Foundation and who submits his results to regular audits of this institution.
Determination of PAPPA-A ( Pregnancy Protein A) is, in addition to the determination of the concentration of the free subunit of ß-hCG, a biochemical test recommended by the Polish Gynecological Society and the FMF (Fetal Medicine Foundation in London) for pregnant women, performed between 11 and 13 weeks of pregnancy. The PAPP-A test (determination of PAPPA-A and the free subunit of ß-HCH) addresses three chromosomal aberrations: Down syndrome, Edwards syndrome and Patau syndrome. 

The interpretation also takes into account the woman's age and the ultrasound result - nuchal translucency assessment, a test also performed between the 11th and 13th weeks of pregnancy. Pregnancy protein A is a glycoprotein, a metalloproteinase secreted by the syncytiotrophoblast. The concentration of PAPPA-A in a pregnant woman's blood increases from the 6th week of pregnancy until delivery. The protein can also be produced by fibroblasts, smooth muscle cells and osteoblasts. The main action of PAPPA-A is immunosuppression, regulation of the delivery of nutrients to the fetus.