Tissue polypeptide antigen (TPA)

TPA - a polypeptide, a fragment of cytokeratins 8,18,19. Expression of the polypeptide antigen has been found in most epithelial cellsórek. TPA is released into the circulation due to destruction of the cellsórek. Increased concentrations can occur during pregnancy, in inflammatory conditions of the lungs, liver and bladder. In addition, an increase in TPA concentrations has been found in the course of benign lesions of the lungs, liver and genitourinary system, as well as in malignant tumors of different organ localization such as breast cancer, cancers of the gastrointestinal tract, ovary, prostate, bladder. TPA, in combination with other markers, is used to monitor therapy and evaluate the effectiveness of cancer treatmentów.