Profile of amino acidsów

Clinical significance

Proteins in food are broken down in the gastrointestinal tract to oligopeptidesów or free amino acidsów and absorbed into the blood. The backbone of someów amino acidsów can be used for glucose synthesis, the combustion of other amino acidsów can be a source of ketone substances. Someów amino acids the body can synthesize on its own (these are so-called endogenous amino acids), while others, such as phenylalanine, isoleucine, leucine, lysine, methionine, tryptophan and valine (so-called essential amino acids) must be supplied with food, because the human body is unable to produce them. Determination of the profile of amino acidsów in the blood has applications in the diagnosis of metabolic disorders. The test makes it possible to determine the concentration of amino acidsów in the examined material (blood serum, móspinal fluid), which allows the possible introduction of an appropriate diet thatóll ensure the correct supply of amino acidsów. The cause of disorders of amino acidów metabolism is a genetically determined deficiency of enzymesów essential for the relevant metabolic pathways. If the disease is diagnosed early, appropriate therapeutic management (appropriate diet) can reduce the consequences of enzyme deficiency. Examples of such disorders: Phenylketonuria (a defect at the level of conversion of the amino acid phenylalanine, in children causes mental retardation, the symptoms of the disease can be reduced by limiting the content of phenylalanine in the diet); alkaptonuria (excess of the amino acid homogentisate, whichówhose excess is excreted in the urine, its derivatives accumulate in tissues, mainly in cartilage - inflammatory changes in the joint may develop); albinism (impaired formation of the amino acid melanin); homocystinuria (impaired production of cysteine from homocysteine, cysteine must be supplied with food).

Patient preparation

Material: heparin plasma