Phenobarbital

Phenobarbital is an antiepileptic drug. The mechanism of action involves, among other things, enhancing synaptic inhibition by acting on gamma-aminobutyric acid (GABA) receptors. The drug has mainly anticonvulsant and sedative effects, and in higher doses, it also inhibits the secretion of thyrotropic hormone thyrotropic hormone, increases the secretion of antidiuretic hormone, has an inhibitory effect on the respiratory center, and reduces tension smooth muscles. Determination of phenobarbital concentration in serum venous blood is performed when poisoning with this drug is suspected In addition, it is helpful in controlling the correct dosage of the of the drug. In this case, the concentration determination is performed at the the moment of the lowest concentration of the drug in the blood, before taking the the next dose.