Nortriptyline

Nortriptyline is the main active metabolite of amitriptyline, formed by N-demethylation. The maximum concentration of of nortriptyline in the serum occurs 8 to 24 hours after the oral administration of amitriptyline - a drug from the group of tricyclic antidepressants. The action of amitriptyline is to blocking the transport of the neurotransmitters norepinephrine and serotonin from the synaptic space back into the neuron. Determination of performed in cases of suspected drug overdose.