Antibodies against ribosomal protein P (IB)

The determination of anti-ribosomal antibodies is performed In the diagnosis of rheumatic diseases. Antibodies to ribosomal protein P (ARPA) may be important in the pathogenesis of autoimmune diseases, including lupus erythematosus systemic. These antibodies can also penetrate the interior of cells, leading to cell dysfunction and apoptosis (cell death) In addition, ARPAs cross-react with cardiolipin, ssDNA, dsDNA and nucleosomes, which may be responsible for adulterating the amount of these antibodies in lupus patients.